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A novel multi-target synthetic small molecule anti-inflammatory agent and a simple one step process for its synthesis

Quick Overview

Features :
* e-Auction called by : Kalam Institute of Health Technology
* e-Auction Type : NonExclusive
* e-Auction Number : NE/KIHT/20034
* TRL : 2
* e-Auction Description of Work : A novel multi-target synthetic small molecule anti-inflammatory agent and a simple one step process for its synthesis
* Base Price : 1000000.00
* Licenses : 20
* e-Auction Category : Prototype Transfer
* e-Auction Date / Time : 31-08-2018 10:56

* The invention provided an anti-inflammatory novel multi-target synthetic small molecule compound having molecular formula (C16H8O7) and Molecular structure (Figure 1) named as DITB.
* The new small molecule lead of the invention find application in the medical field, for the treatment of pathological condition that includes, but not limited to inflammation, pain, metabolic syndrome and cancer
* Small molecule compound DITB, capable of modulating COX-1, COX-2, iNOS and AMPK enzymes by molecular docking method.
* In addition, the preliminary in vitro and in vivo studies establish the positive results of DITB in pre-clinical models of inflammation.
* Moreover, the present invention provided a lead structure to design and develop multi-target anti-inflammatory small molecule compounds that can be applied for the beneficial effects in the field of anti-inflammatory and related diseases.
Need and Demand :
* The strategy of employing multi-target molecules in chronic inflammation and related disorders appears to be built on sound academic principles and serves to signal a paradigm shift in contemporary approaches towards drug discovery
* Balanced modulation ’! Many relevant & interconnected targets/Signalling switches ’! Superior & More efficient in combating complex inflammatory disorders peculiar to life style diseases.
Market Access Information :
* Global anti-inflammatory therapeutics market is expected to reach USD 130.6 Billion by 2026, with CAGR of 8.5% from 2018  2026

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Specification :
* A novel multi-target synthetic small molecule anti-inflammatory agent and a simple one step process for its synthesis

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